PathHunter® U2OS BMPR1B/ACVR2B Dimerization Cell Line

The PathHunter® U2OS BMPR1B/ACVR2B Dimerization Cell Line measures ligand-induced dimerization of BMPR1B/ACVR2B . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1052C3 Size: 2 vials

Inquire

Biological Information
Background Information:	The PathHunter® BMPR1B/ACVR2B Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. BMP-6) induced dimerization of BMPR1B/ACVR2B receptors. This product uses EFC technology. The cell line included overexpresses ACVR2B target protein fused to PK alongside BMPR1B target protein fused to EA. Upon ligand-induced dimerization of BMPR1B/ACVR2B , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Kinase
Family:	Ser/Thr Kinase: Type I Receptor
Sub Family:	Protein Ser/Thr
Accession Number:	NM_001256793.1
Target Name:	BMPR1B/ACVR2B
Target Aliases:	bone morphogenetic protein receptor, bone morphogenetic protein receptor type IB, Activin receptor, Activin A receptor type IIB, ALK-6, ALK6, AMD3, AMDD, BDA1D, BDA2, CDw293, ACTRIIB, ActR-IIB, HTX4
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®