PathHunter® NCI-H460 CDC25A Degradation Cell Line

The PathHunter® NCI-H460 CDC25A Degradation Cell Line measures pathway activation-induced degradation of CDC25A target protein. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0776C12 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® NCI-H460 CDC25A Degradation Cell Line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting the cell cycle checkpoint pathway. This cell line enables detection of levels of CDC25a, allowing for assessment of CHK-1-activation-induced CDC25a degradation. This product uses EFC technology. The cell line included overexpresses CDC25a target protein fused to PL. EA is contained in the detection reagent. Upon pathway-activation-induced degradation of CDC25a EFC signal is lost. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Phosphatase
Family:	Dual-Specific Phosphatase
Sub Family:	Protein Tyrosine
Accession Number:	NM_001789.2
Target Name:	CDC25A
Target Aliases:	Cell division cycle 25 homolog A
Target Species:	Human
Cell Background:	NCI-H460

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Degradation
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®