PathHunter® BTLA Signaling Cell Line (Jurkat)

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The PathHunter® BTLA Signaling Cell Line (Jurkat) measures BTLA signal by recruitment of SH2 domain protein to the activated receptor. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1112C19 Size: 2 vials
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Biological Information
Background Information:
The PathHunter® BTLA Signaling Cell Line (Jurkat) is a stable, engineered cell line for use in studying molecules and drug candidates targeting signaling checkpoints. This cell line enables assessment of BTLA induced non-canonical NF-κB signaling via detection of SH2 domain protein recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged BTLA target protein and EA-tagged SH2 domain protein. Upon activation of the receptor by its ligand or an agonist antibody, recruitment of SH2 domain protein to the phosphorylated receptor tail leads to production of EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
Checkpoint Receptor
Target Name:
BTLA
Target Species:
Human
Cell Background:
Jurkat
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Functional
Assay Measures:
Signaling
Detection Method:
Chemiluminescence
Additional Information
Brand:
PathHunter®

User Manuals & Protocols

70-394 PathHunter Checkpoint Signaling Assay-IgSF_REV3

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Datasheets

93-1112C19

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