PathHunter® HepG2 IL11R STAT3 Signaling Pathway Reporter Cell Line

The PathHunter® HepG2 IL11R STAT3 Signaling Pathway Reporter Cell Line overexpresses IL11R and measures STAT3 pathway activation through detection of induced expression levels of a tagged reporter protein. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1168C044 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® HepG2 IL11R STAT3 Signaling Pathway Reporter Cell Line is a stable, engineered cell line that overexpresses IL11R. It can be used for studying drug candidates (small molecules or biologics) affecting the STAT3 pathway. This cell line enables assessment of STAT3 pathway stimulation based on changes in the expression of a STAT3 response element-driven reporter protein. This product uses EFC technology. The included cell line expresses PL-tagged reporter protein under the control of a STAT3 pathway-inducible transcriptional response element. Pathway activation induces expression of the PL-tagged protein, allowing detection of EFC signal upon addition of EA-containing detection reagent. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Cytokine Receptor
Family:	Interleukin Receptor
Accession Number:	NM_001142784.2
Target Name:	IL11R STAT3
Target Aliases:	interleukin 11 receptor, alpha
Target Species:	Human
Cell Background:	HepG2

Usage
Product Type:	Stable Cell Lines
Application:	Signaling Reporters
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Signaling
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®