PathHunter® HEK 293 IFNAR1/IFNAR2 Dimerization Cell Line

The PathHunter® HEK 293 IFNAR1/IFNAR2 Dimerization Cell Line measures ligand-induced dimerization of IFNAR1/IFNAR2 . This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1097C1 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® IFNAR1/IFNAR2 Dimerization cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting receptor-receptor interaction. This cell line enables assessment of ligand (e.g. IFN-beta) induced dimerization of IFNAR1/IFNAR2 receptors. This product uses EFC technology. The cell line included overexpresses IFNAR2 target protein fused to PK alongside IFNAR1 target protein fused to EA. Upon ligand-induced dimerization of IFNAR1/IFNAR2 , detectable EFC signal is produced. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	Cytokine Receptor
Family:	Interferon Receptor Family
Accession Number:	NM_000629.2
Target Name:	IFNAR1/IFNAR2
Target Aliases:	interferon receptor, interferon alpha and beta receptor subunit 1, interferon alpha and beta receptor subunit 2, AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC, IMD106, IFN-R, IFN-R-2, IFN-alpha-REC, IFNABR, IFNARB, IMD45
Target Species:	Human
Cell Background:	HEK293

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Dimerization
Detection Method:	Chemiluminescence

Clinical Relevance
Therapeutic Area:	Inflammation/Allergy

Additional Information
Brand:	PathHunter®