PathHunter® FGFR1v3B Functional Cell Line (U20S)

The PathHunter® FGFR1v3B Functional Cell Line (U20S) measures FGFR1 receptor tyrosine kinase activity via ligand-induced SH2 domain protein recruitment. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-1025C3 Size: 2 vials

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Biological Information
Background Information:	PathHunter® RTK Functional cell lines are engineered to co-express a ProLink™ (PK) tagged RTK, an Enzyme Acceptor (EA) tagged SH2 domain, and, in some cases, an untagged co-receptor. Activation of the RTK-PK induces receptor dimerization, leading to SH2-EA recruitment, and forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.
Target Class:	Kinase
Family:	Receptor Typosine Kinase (RTK): Growth Factor Receptor
Sub Family:	Protein Tyrosine
Accession Number:	NC_000008.11
Target Name:	FGFR1
Target Aliases:	BFGFR, CD331, CEK, ECCL, FGFBR, FGFR-1, FLG, FLT-2, FLT2, HBGFR, HH2, HRTFDS, KAL2, N-SAM, OGD, bFGF-R-1
Target Species:	Human
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Functional Activity

Clinical Relevance
Therapeutic Area:	Oncology/Immuno-Oncology

Additional Information
Brand:	PathHunter®