PathHunter® CHO-K1 P2RY8 β-Arrestin Orphan GPCR Cell Line

The PathHunter® CHO-K1 P2RY8 β-Arrestin Orphan GPCR Cell Line measures P2RY8 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0635C2 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® P2RY8 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. UTP) based activation of P2RY8 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged P2RY8 and EA-tagged β-Arrestin 2. Activation of P2RY8 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Class A Orphans
Sub Family:	Class A
Accession Number:	NM_178129
Target Name:	P2RY8
Target Aliases:	Purinergic receptor P2Y, G-protein coupled, 8, P2Y8
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	β-Arrestin Recruitment
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®