PathHunter® CHO-K1 OXGR1 β-Arrestin Orphan GPCR Cell Line

The PathHunter® CHO-K1 OXGR1 β-Arrestin Orphan GPCR Cell Line measures OXGR1 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0693C2 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® OXGR1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. alpha-ketoglutaric acid) based activation of OXGR1 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged OXGR1 and EA-tagged β-Arrestin 2. Activation of OXGR1 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Oxoglutarate Receptor
Sub Family:	Class A
Coupling:	Gq
Accession Number:	NM_080818.3
Target Name:	OXGR1 (GPR80, GPR99)
Target Aliases:	Oxoglutarate (alpha-ketoglutarate) receptor 1, 2-oxoglutarate receptor 1, G protein-coupled receptor 80, G protein-coupled receptor 99, G-protein coupled receptor 80, G-protein coupled receptor 99, GPR80, GPR99, P2RY15, P2Y purinoceptor 15, P2Y-like GPCR, P2Y-like nucleotide receptor, P2Y15, alpha-ketoglutarate receptor 1, oxoglutarate (alpha-ketoglutarate) receptor 1, seven transmembrane helix receptor
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
β-Arrestin isoform:	β-Arrestin-2
Assay Measures:	β-Arrestin Recruitment
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®