PathHunter® CHO-K1 OXER1 β-Arrestin Cell Line

The PathHunter® CHO-K1 OXER1 β-Arrestin Cell Line measures OXER1 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0867C2 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® OXER1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. 5-oxo-ETE) based activation of OXER1 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged OXER1 and EA-tagged β-Arrestin 2. Activation of OXER1 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Leukotriene Receptors
Coupling:	Gi/Go
Accession Number:	NM_148962.4
Target Name:	OXER1
Target Aliases:	Oxoeicosanoid (OXE) receptor 1
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
β-Arrestin isoform:	β-Arrestin-2
Assay Measures:	β-Arrestin Recruitment
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®