PathHunter® CHO-K1 mNPY2R β-Arrestin Cell Line

The PathHunter® CHO-K1 mNPY2R β-Arrestin Cell Line measures mNPY2R (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells. Mouse protein.

Catalog #: 93-0569C2 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® mNPY2R cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. peptide YY) based activation of mNPY2R GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged mNPY2R and EA-tagged β-Arrestin 2. Activation of mNPY2R stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.
Target Class:	GPCR
Family:	Neuropeptide Y Receptors
Coupling:	Gi/Go & Gq
Accession Number:	NM_008731.3
Target Name:	NPY2R
Target Aliases:	Neuropeptide Y receptor Y2, NPY2-R, Neuropeptide Y2 receptor
Target Species:	Mouse
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
β-Arrestin isoform:	β-Arrestin-2
Assay Measures:	β-Arrestin Recruitment
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®