PathHunter® CHO-K1 mMC4R β-Arrestin Cell Pool

The PathHunter® mMC4R Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. α-MSH) based activation of mMC4R GPCR activity via detection of β-arrestin recruitment.

Catalog #: 93-0608P2 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® mMC4R Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell pool enables assessment of ligand (e.g. α-MSH) based activation of mMC4R GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mMC4R and EA-tagged β-Arrestin-2. Activation of mMC4R stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.
Target Class:	GPCR
Family:	Melanocortin Receptors
Accession Number:	NM_016977.1
Target Name:	MC4R
Target Aliases:	Pkcp, Mc4-r, Melanocortin receptor 4
Target Species:	Mouse
Cell Background:	CHO-K1

Usage
Product Type:	Cell Pool
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	β-Arrestin Recruitment
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®