PathHunter® CHO-K1 mHCRTR1 β-Arrestin Cell Pool

The PathHunter® mHCRTR1 Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. orexin A) based activation of mHCRTR1 GPCR activity via detection of β-arrestin recruitment.

Catalog #: 93-0606P2 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® mHCRTR1 Cell Pool is a stable, engineered cell pool for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. orexin A) based activation of mHCRTR1 GPCR activity via detection of β-arrestin recruitment. The included cell pool overexpresses ProLink-tagged mHCRTR1 and EA-tagged β-Arrestin-2. Activation of mHCRTR1 stimulates the recruitment of β-Arrestin-2 and produces EFC signal. This stable cell pool is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.
Target Class:	GPCR
Family:	Orexin Receptors
Accession Number:	NM_198959.2
Target Name:	HCRTR1 (OX1 receptor)
Target Aliases:	Orexin receptor 1, ORXR1, OX1R, OXR1
Target Species:	Mouse
Cell Background:	CHO-K1

Usage
Product Type:	Cell Pool
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	β-Arrestin Recruitment
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®