PathHunter® CHO-K1 mEDG1 β-Arrestin Cell Line

The PathHunter® CHO-K1 mEDG1 β-Arrestin Cell Line measures mEDG1 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells. Mouse protein.

Catalog #: 93-0476C2 Size: 2 vials

Inquire

Biological Information
Background Information:	The PathHunter® mEDG1 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. S1P) based activation of mEDG1 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged mEDG1 and EA-tagged β-Arrestin 2. Activation of mEDG1 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.
Target Class:	GPCR
Family:	Lysophospholipid (S1P) Receptors
Coupling:	Gi/Go
Accession Number:	NM_007901
Target Name:	EDG1
Target Aliases:	Sphingosine 1-phosphate receptor 1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, S1PR1, S1P1
Target Species:	Mouse
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
β-Arrestin isoform:	β-Arrestin-2
Assay Measures:	β-Arrestin Recruitment
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®