PathHunter® CHO-K1 CRTH2 β-Arrestin Cell Line

The PathHunter® CHO-K1 CRTH2 β-Arrestin Cell Line measures CRTH2 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0291C2 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® CRTH2 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. prostaglandin D2) based activation of CRTH2 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged CRTH2 and EA-tagged β-Arrestin 2. Activation of CRTH2 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Prostanoid Receptors
Accession Number:	AY507142
Target Name:	CRTH2 / PTGDR2 / DP2
Target Aliases:	Prostaglandin DP2 receptor, CD294, PTGDR2, DL1R, DP2, GPR44
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
β-Arrestin isoform:	β-Arrestin-2
Assay Measures:	β-Arrestin Recruitment
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®