PathHunter® C2C12 CXCR5 β-Arrestin Cell Line

The PathHunter® C2C12 CXCR5 β-Arrestin Cell Line measures CXCR5 (GPCR) activity via recruitment of β-Arrestin2. This cell line ships as two vials of cryopreserved cells.

Catalog #: 93-0204C7 Size: 2 vials

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Biological Information
Background Information:	The PathHunter® CXCR5 cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. [ligand]) based activation of CXCR5 GPCR activity via detection of β-arrestin recruitment. This product uses EFC technology. The included cell line overexpresses PK-tagged CXCR5 and EA-tagged β-Arrestin 2. Activation of CXCR5 stimulates the recruitment of β-Arrestin 2 and produces EFC signal. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Chemokine Receptors
Sub Family:	Class A
Coupling:	Gi/Go
Accession Number:	NM_001716
Target Name:	CXCR5 (BLR-1)
Target Aliases:	Burkitt lymphoma receptor, BLR1, CD185, MDR15, CXCR5, CXCR5, Chemokine
Target Species:	Human
Cell Background:	C2C12

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
β-Arrestin isoform:	β-Arrestin-2
Assay Measures:	β-Arrestin Recruitment
Detection Method:	Chemiluminescence

Additional Information
Brand:	PathHunter®