| Biological Information | |
|---|---|
| Background Information: | JMJD2E (Jumonji domain-containing protein 2E), also known as KDM4E, is a histone demethylase that belongs to the JmjC domain-containing protein family. Like other members of this family, JMJD2E specifically targets di- and tri-methylated lysine residues on histones H3 and H4, and catalyzes their removal, leading to changes in chromatin structure and gene expression.
JMJD2E is expressed in a variety of tissues, including the brain, heart, and liver, and is involved in the regulation of various cellular processes, including differentiation, proliferation, and apoptosis.
JMJD2E has been implicated in the development of several types of cancer, including breast, ovarian, and prostate cancers. Additionally, recent studies have suggested that JMJD2E is involved in the regulation of pluripotency and differentiation of embryonic stem cells. Therefore, JMJD2E has emerged as a potential target for the development of novel therapeutics for cancer, metabolic diseases, and regenerative medicine. |
| Target Class: | Epigenetic Protein |
| Accession Number: | Refer to CoA for Accession Number |
| Target Name: | JMJD2E |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
JMJD2E
N-terminal 6His-tagged recombinant amino acids 1-336, human JMJD2E.
Datasheets
EPI033 Datasheet
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