| Biological Information | |
|---|---|
| Background Information: | DOT1L (disruptor of telomeric silencing 1-like) is an epigenetic protein that functions as a histone methyltransferase. It is responsible for adding methyl groups to specific lysine residues on histones, leading to the formation of heterochromatin and repression of gene expression. DOT1L is widely expressed in many tissues and is important for normal development and cellular function. It is involved in various biological processes, including transcriptional regulation, DNA damage response, and cell cycle progression.
Aberrant DOT1L activity has been implicated in various diseases, including cancer, leukemia, and neurodevelopmental disorders. DOT1L inhibitors are being developed for therapeutic purposes, and understanding its function is important for developing new therapies. |
| Target Class: | Epigenetic Protein |
| Accession Number: | Refer to CoA for Accession Number |
| Target Name: | DOT1L |
| Target Species: | Human |
| Usage | |
| Product Type: | Enzymes |
| Application: | Drug Discovery & Development |
| Storage Conditions: | 1 year at -70°C |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
DOT1L
Recombinant human DOT1L amino acids 1-420.
Datasheets
EPI018 Datasheet
View Document