CHO-K1 F2RL1 Gq Cell Line

The CHO-K1 F2RL1 Gq Cell Line measures F2RL1 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

Catalog #: 95-1006C2 Size: 2 vials

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Biological Information
Background Information:	The F2RL1 Gq cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. serine proteases, SLIGRL-NH2) based activation of F2RL1 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses F2RL1 , a naturally Gq coupled GPCR. Upon activation of F2RL1 , the resulting calcium activity can be fluorescently assayed using the Calcium NoWash PLUS Detection Kit. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Proteinase-Activated Receptors
Coupling:	Gi/Go & Gq
Accession Number:	NM_005242.4
Target Name:	F2RL1 (PAR2,GPR11)
Target Aliases:	Coagulation factor II (thrombin) receptor-like 1 (PAR2), F2RL1, PAR2, Proteinase-Activated, GPR11, PAR2
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	Calcium Flux
Detection Method:	Chemiluminescence

Additional Information
Brand:	DiscoverX