ChemiScreen™ CCR10 Chemokine Receptor Stable Cell Line

Awaiting product image

The ChemiScreen™ CCR10 Chemokine Receptor Stable Cell Line measures CCR10 (GPCR) activation via an increase in intracellular calcium. This cell line ships as two vials of cryopreserved cells.

Catalog #: HTS014C Size: 2 vials
Inquire
Biological Information
Background Information:
The ChemiScreen™ CCR10 Chemokine Receptor Stable Cell Line is an engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. CCL27) based activation of CCR10 GPCR activity via detection of increasing levels of intracellular calcium. The included cell line overexpresses CCR10 alongside endogenous high levels of the promiscuous G protein, Gα15, coupling the receptor to the calcium signaling pathway. Upon activation of CCR10 , the resulting calcium activity can be fluorescently assayed. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:
GPCR
Family:
Chemokine Receptors
Accession Number:
AF215981
Target Name:
CCR10
Target Aliases:
Chemokine (C-C motif) receptor 10, CCR10, CCR10, Chemokine
Target Species:
Human
Usage
Product Type:
Stable Cell Lines
Application:
Drug Discovery & Development
Storage Conditions:
Store in vapor phase of liquid nitrogen.
Usage Disclaimer:
These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Measures:
Calcium Flux
Detection Method:
Fluorescence
Additional Information
Brand:
ChemiSCREEN™

User Manuals & Protocols

70-427 ChemiSCREEN and ChemiBRITE Cell Lines User Manual REV1

View Document

Datasheets

HTS014C Datasheet

View Document