cAMP Hunter™ U2OS mGLP1R Gs Cell Line

The cAMP Hunter™ U2OS mGLP1R Gs Cell Line measures mGLP1R (GPCR) activity via increased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells. Mouse version.

Catalog #: 95-0179C3 Size: 2 vials

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Biological Information
Background Information:	The cAMP Hunter™ mGLP1R Gs cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. exendin-4) based activation of mGLP1R GPCR activity via detection of increasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type mGLP1R , a naturally Gs coupled GPCR. Upon activation of mGLP1R , the increase in levels of intracellular cAMP leads to an increased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Mouse version of this protein.
Target Class:	GPCR
Family:	Glucagon Receptor Family
Coupling:	Gs
Accession Number:	NM_021332
Target Name:	GLP1R
Target Aliases:	Glucagon-like peptide receptor 1, GLP-1R, GLP1Rc
Target Species:	Mouse
Cell Background:	U2OS

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	cAMP Detection
Detection Method:	Chemiluminescence

Clinical Relevance
Therapeutic Area:	Metabolic Diseases

Additional Information
Brand:	cAMP Hunter™