cAMP Hunter™ CHO-K1 SSTR5 Gi Cell Line

The cAMP Hunter™ CHO-K1 SSTR5 Gi Cell Line measures SSTR5 (GPCR) activity via increased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

Catalog #: 95-0133C2 Size: 2 vials

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Biological Information
Background Information:	The cAMP Hunter™ SSTR5 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. somatostatin 28) based activation of SSTR5 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type SSTR5 , a naturally Gi/Go coupled GPCR. Upon activation of SSTR5 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Somatostatin Receptors
Sub Family:	Class A
Coupling:	Gi/Go
Accession Number:	NM_001053
Target Name:	SSTR5
Target Aliases:	Somatostatin receptor 5, SS-5-R, SST5
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	cAMP Detection
Detection Method:	Chemiluminescence

Additional Information
Brand:	cAMP Hunter™