cAMP Hunter™ CHO-K1 rDRD2S (Short Isoform) Gi Cell Line

The cAMP Hunter™ CHO-K1 rDRD2S (Short Isoform) Gi Cell Line measures rDRD2S (GPCR) activity via increased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells. Rat version.

Catalog #: 95-0129C2 Size: 2 vials

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Biological Information
Background Information:	The cAMP Hunter™ rDRD2S Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. dopamine, pergolide) based activation of rDRD2S GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type rDRD2S , a naturally Gi/Go coupled GPCR. Upon activation of rDRD2S , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells. Please note that this product expresses the Rat version of this protein.
Target Class:	GPCR
Family:	Dopamine Receptors
Coupling:	Gi/Go
Accession Number:	M36831
Target Name:	DRD2 (S)
Target Aliases:	Dopamine receptor D2
Target Species:	Rat
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	cAMP Detection
Detection Method:	Chemiluminescence

Additional Information
Brand:	cAMP Hunter™