cAMP Hunter™ CHO-K1 NPBWR1 Gi Cell Line

The cAMP Hunter™ CHO-K1 NPBWR1 Gi Cell Line measures NPBWR1 (GPCR) activity via increased levels of intracellular cAMP. This cell line ships as two vials of cryopreserved cells.

Catalog #: 95-0099C2 Size: 2 vials

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Biological Information
Background Information:	The cAMP Hunter™ NPBWR1 Gi cell line is a stable, engineered cell line for use in studying drug candidates (small molecules or biologics) targeting GPCRs. This cell line enables assessment of ligand (e.g. neuropeptides B and W) based activation of NPBWR1 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type NPBWR1 , a naturally Gi/Go coupled GPCR. Upon activation of NPBWR1 , the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. This stable modified cell line is provided as two vials of cryopreserved cells.
Target Class:	GPCR
Family:	Neuropeptide W/ Neuropeptide B Receptors
Sub Family:	Class A
Coupling:	Gi/Go
Accession Number:	NM_005285
Target Name:	NPBWR1
Target Aliases:	Neuropeptides B/W receptor 1, NPBWR1, GPR7, Neuropeptide B & W
Target Species:	Human
Cell Background:	CHO-K1

Usage
Product Type:	Stable Cell Lines
Application:	Drug Discovery & Development
Storage Conditions:	Store in vapor phase of liquid nitrogen.
Usage Disclaimer:	These products may be covered by issued US and/or foreign patents, patent application and subject to Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.

Assay Information
Assay Type:	Functional
Assay Measures:	cAMP Detection
Detection Method:	Chemiluminescence

Additional Information
Brand:	cAMP Hunter™