| Biological Information | |
|---|---|
| Background Information: | The cAMP Hunter™ Tirzepatide (GLP-1 RA) Bioassay Kit has been qualified with Tirzepatide. This bioassay provides a robust, and highly sensitive functional, cell-based assay to monitor 3’-5’-cyclic adenosine monophosphate (cAMP) production in cells, as a result of Tirzepatide-mediated activation of the GLP-1 receptor. The bioassay kit contains all the materials needed for a complete assay, including cells, detection reagents, cell plating reagent, positive control agonist, and assay plates. The ready-to-use cryopreserved cells have been manufactured to ensure assay reproducibility and faster implementation from characterization to QC lot-release. This bioassay has been optimized for a 96-well format. Note that control agonist for stimulating the cells, recombinant human Exendin-4, may not be included in the kit, and may be purchased separately. Tirzepatide is the first dual GLP-1/GIP receptor agonist (RA) approved for type 2 diabetes and obesity. |
| Target Class: | GPCR |
| Family: | Glucagon |
| Sub Family: | Class B |
| Accession Number: | NM_002062.3 |
| Target Name: | GLP1R |
| Target Aliases: | Glucagon-like peptide receptor 1, GLP-1, GLP-1-R, GLP-1R, GLP1, GLP1R |
| Target Species: | Human |
| Cell Background: | CHO-K1 |
| Usage | |
| Product Type: | Bioassay Kits |
| Application: | Potency; Commercial Release & Stability |
| Storage Conditions: | Store in vapor phase of liquid nitrogen. |
| Usage Disclaimer: | These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information. |
| Assay Information | |
| Assay Type: | Functional |
| Assay Measures: | cAMP Detection |
| Detection Method: | Chemiluminescence |
| Bioassay Data | |
| INN Drug Name: | Tirzepatide |
| Trademark Statement: | Mounjaro® is a registered trademark of Eli Lilly and Company |
| Clinical Relevance | |
| Therapeutic Area: | Metabolic Diseases |
| Additional Information | |
| Brand: | cAMP Hunter™ |
cAMP Hunter™ Tirzepatide (GLP-1 RA) Bioassay Kit
The cAMP Hunter™ Tirzepatide (GLP-1 RA) Bioassay Kit is a qualified bioassay that provides an easy-to-use cell based assay to measure drug potency and detect neutralizing antibodies. This bioassay provides a robust, and highly sensitive functional, cell-based assay to monitor 3’-5’-cyclic adenosine monophosphate (cAMP) production in cells, as a result of Tirzepatide-mediated activation of the GLP-1 receptor.
View bioassay qualification data.
User Manuals & Protocols
70-447_ cAMP Hunter Tirzepatide (GLP-1 RA) Bioassay Kit User Manual- Rev0_final
View DocumentDatasheets
95-0062Y2 Datasheet
View Document