SRPK1, active

Background Information:

Two SR Protein-specific Kinases, SRPK1 and SRPK2, have been shown to phosphorylate specifically the RS motifs of the SR family of splicing factors. Phosphorylation of an SR protein (ASF/SF2) by either SRPk1 or 2 enhanced its interaction with another RS domain-containing protein, and overexpression of either kinase induced specific redistribution of splicing factors in the nucleus. SRPK1 is considered to be a constitutively active kinase predominantly active in testis. Inhibition of SRPK1 may render male germ cell and other tumors insensitive to cisplatin. GenBank NM_003137

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

SRPK1

Protein Aliases:

SR protein kinase 1|serine/arginine-rich splicing factor kinase 1

Accession Number:

NM_003137.3

UniProt Number:

Q96SB4

Gene Name:

SRPK1

Gene ID:

6732

Gene Aliases:

SFRSK1

Target Species:

Human