Biological Information
Background Information:
The Lyn protein is a member of the Src family of non-receptor-associated protein-tyrosine kinases. LYN A differs from LYN B in having an additional 21 amino acids at the amino terminus. Lyn undergoes a concentration-dependent autophosphorylation, thus activating the catalytic site and decreasing the accessibility of the SH2 domain. Lyn phosphorylates and activates Tec, non-receptor tyrosine kinase that is coexpressed with Lyn and acts downstream of Lyn in intracellular signaling pathways. Lyn tyrosine kinase has been shown to be necessary for IgE-receptor (FceRI)-mediated mast-cell activation. EMBL M16038
Target Class:
Kinase
Family:
TK
Sub Family:
Protein Tyrosine
Protein Name:
LYN
Protein Aliases:
Lck/Yes-related novel protein tyrosine kinase|V-yes-1 Yamaguchi sarcoma viral related oncogene homolog|p53Lyn|p56Lyn
Accession Number:
NM_002350.1
UniProt Number:
P07948
Gene Name:
LYN
Gene ID:
4067
Gene Aliases:
JTK8
Target Species:
Human
Usage
Product Type:
Enzymes
Application:
Drug Discovery & Development
Storage Conditions:
1 year at -70°C
Usage disclaimer:
These products may be covered by issued US and/or foreign patents, patent applications and subject to a Limited Use Label License. Please visit discoverx.com/license for a list of products that are governed by limited use label license terms and relevant patent and trademark information.
Assay Information
Assay Type:
Enzymatic
Bioassay Data
Trademark Statement:
For Research Use Only
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy