Checkpoint Receptor Assays
MOA-reflective, functional cell-based assays to analyze signaling, dimerization, internalization, & clustering/crosslink
Cytokine Receptor Product Solutions
Functional, MOA-reflective assays targeting human cytokine receptors for screening, characterization, QC lot release, &
Epigenetic Protein Product Solutions
Epigenetics target-based drug development products including bromodomain & methyltransferase target engagement cell line
GPCR Product Solutions
GPCR cell-based functional assays for detecting ligand binding, second messengers, beta-arrestin recruitment, & GPCR int
Helicase Product Solutions
Validated, full-length recombinant helicases for robust screening, structural insights, & advanced mechanism of action r
Ion Channel Solutions
Pharmacologically & functionally validated ion channel cell lines including voltage-gated, ligand-gated & others for dru
Kinase Product Solutions
Kinase recombinant enzymes & functional & binding assays to assess kinase binding, receptor activation, dimerization, ph
Nuclear Protein Product Solutions
Functional cell-based assays to study nuclear protein translocation to the nucleus & ligand-induced activation of nuclea
Signaling Pathway Product Solutions
Signal transduction pathway assays assess targets like BCL2, TORC, p53, NF-kB, etc. for various pathways including apopt
Recombinant GPCR Proteins
Active recombinant GPCR proteins designed to facilitate deeper understanding of GPCR signaling and accelerate the discov
Ubiquitination Proteins
Active recombinant proteins involved in ubiquitination for robust screening, structural insights, & advanced mechanism o
Checkpoint Agonist Antibody Assays
Mechanistically relevant cell-based agonist antibody assays to evaluate and characterize agonism of antibodies targeting
Kinase Activity Assay Kits
Validated, ready-to-use enzyme activity assays to assess small molecule enzyme & kinase inhibitors in drug discovery
Receptor Tyrosine Kinase Assays
Cell-based functional assays to assess dimerization, phosphorylation, internalization, & SH2-recruitment of RTK & cytoki
ADP Accumulation Assays
ADP accumulation assays detect kinase activity & inhibition by measuring ADP accumulation in antibody-free and homogeneo
GPCR Calcium Product Solutions
Measure intracellular calcium flux via GPCR signaling using cell line assay kits, stable cell lines, ready-to-assay kits
GPCR cAMP Product Solutions
Detect cellular cAMP levels via GPCR signaling by biologics or small molecule therapeutics using robust, simple, homogen
GPCR β-Arrestin Product Solutions
Universal G-protein independent cell-based assays to measure GPCR beta-arrestin recruitment and subsequent internalizati