Biological Information

Background Information:

PRKX (Protein Kinase X-Linked) is regulated by and mediating cAMP signaling in cells. It acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. It also regulates myeloid cell differentiation through SMAD6 phosphorylation. In addition, PRKX is involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis, and also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. GenBank NM_005044

Target Class:

Kinase

Family:

AGC

Sub Family:

Protein Ser/Thr

Protein Name:

PRKX

Protein Aliases:

Protein kinase X|Protein kinase X-linked|Serine/threonine-protein kinase PRKX|Protein kinase PKX1

Accession Number:

NM_005044.2

UniProt Number:

P51817

Gene Name:

PRKX

Gene ID:

5613

Gene Aliases:

PKX1

Target Species:

Human

Usage

Product Type:

Enzymes

Application:

Drug Discovery & Development

Storage Conditions:

1 year at -70°C

Usage disclaimer:

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Assay Information

Assay Type:

Enzymatic

Bioassay Data

Trademark Statement:

For Research Use Only

Clinical Relevance

Therapeutic Area:

Metabolic Diseases