Cdk7/Cyclin H/MAT1 (CAK complex), active

Background Information:

Cyclin-dependent Kinase 7 (cdk7) is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle. GenBank X79193 / GenBank U11791 / GenBank X87843

Target Class:

Kinase

Family:

CMGC

Sub Family:

Protein Ser/Thr

Protein Name:

CDK7

Protein Aliases:

39 kDa protein kinase|p39 Mo15|CDK-activating kinase 1|Cell division protein kinase 7|Serine/threonine-protein kinase 1|TFIIH basal transcription factor complex kinase subunit

Accession Number:

NM_001799.2

UniProt Number:

P50613

Gene Name:

CDK7

Gene ID:

1022

Gene Aliases:

CAK1|CDKN7|MO15|STK1|CAK

Target Species:

Human