ASK1, active

Background Information:

Apoptosis signal-regulating kinase 1 (ASK1) is a serine/threonine protein kinase and identified as a MAPKKK which activates the c-Jun N-terminal kinase (JNK) and p38 MAP kinase pathways and is required for TNFalpha;-induced apoptosis. ASK1 suggests possible mechanisms for redox regulation of the apoptosis signal transduction pathway as well as the effects of antioxidants against cytokine- and stress-induced apoptosis. GenBank NM_005923

Target Class:

Kinase

Family:

STE

Sub Family:

Protein Ser/Thr

Protein Name:

ASK1

Protein Aliases:

apoptosis signal regulating kinase 1

Accession Number:

NM_005923.3

UniProt Number:

Q99683

Gene Name:

MAP3K5

Gene ID:

4217

Gene Aliases:

MAPKKK5|ASK1|MEKK5

Target Species:

Human