mTOR (1362-end), active

Background Information:

mTOR (Mechanistic Target Of Rapamycin Kinase) belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. GenBank NM_004958

Target Class:

Kinase

Family:

PIKK

Sub Family:

Atypical

Protein Name:

mTOR

Protein Aliases:

FK506 binding protein 12-rapamycin associated protein 2|rapamycin target protein|FKBP12-rapamycin complex-associated protein 1|FKBP-rapamycin associated protein|rapamycin associated protein FRAP2|dJ576K7.1 (FK506 binding protein 12-rapamycin associated protein 1)|rapamycin and FKBP12 target 1|mammalian target of rapamycin

Accession Number:

NM_004958.2

UniProt Number:

P42345

Gene Name:

MTOR

Gene ID:

2475

Gene Aliases:

RAFT1|RAPT1|FLJ44809

Target Species:

Human