Roundtable Webinar: Accelerating Your Biologics Therapeutics Development with Bioassays

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Roundtable Webinar: Accelerating Your Biologics Therapeutics Development with Bioassays

 

Bioassays serve as a critical component of the quality control (QC) system for characterising biologics and are needed to support lot release, comparability, product stability and neutralising antibody (NAb) testing. Given the stringent regulatory requirements, developing QC-suitable robust bioassays that reflect the biologics mechanism-of-action (MOA) is never an easy task!


In addition, biologics are becoming even more complex with evolving protein-engineering technologies further challenging the established approaches for bioassay development.


This roundtable webinar will present an interactive panel discussion with industry leaders from global contract research, development and manufacturing organisations (CROs/CDMOs) on development strategies, current trends, lessons learned and evolving approaches for bioassays.




Register Now
Event capacity: N/A
Event location:
Event date: 7/28/2022, 8:00 AM - 9:00 AM
Event Date ▼ Event Name PDF Link Webinar Link
June 16, 2022 Webinar: Cytotoxicity Bioassays – Measuring Antibody-Mediated Direct Cell Death
February 23, 2022 Webinar: Unlocking Orphan GPCRs with an Innovative Forward Trafficking Approach – 45 min. + 30 min. Q&A
July 28, 2021 Webinar: Automating Functional Cell-based Bioassays: Assay Reproducibility and Performance for Potency Testing Programs - 45 min.
March 30, 2021 Webinar: Novel Small Molecule Inhibitors of Oncogenic SHP2 Variants Characterized by Cellular Target Engagement - 45 min.
October 28, 2020 Webinar: Accelerating COVID-19 Drug Discovery: Qualified Cell-Based Assays for Proinflammatory Cytokines - 45 min.
June 17, 2020 Webinar: Simple Signaling Reporter Assays – Easily Quantify Activation & Inhibition of Cellular Pathways - 30 min.
February 26, 2020 Webinar: Protein Degradation (PROTACs/CRISPR) Assays - 60 min.
October 9, 2019 Webinar: Establishing Qualified Bioassays for Checkpoint Receptors to Implement in QC Lot Release: Case Studies on PD-1 and SIRPα - 60 min.
May 9, 2018 Webinar: Accelerate Biologics and Biosimilars Development: Case Studies Implementing Robust and Simple Potency Bioassays - 60 min.
November 1, 2017 Webinar: How to Accelerate Your Biotherapeutic Development with Cell-Based Assay Services - 40 min.

What will be covered?

  • How PathHunter services save development time compared to in-house assays
  • Screening and profiling biologics with highly specific and sensitive assays that produce robust and reproducible results
  • Example data from marketed drugs, like Pembrolizumab and Nivolumab, using these cell-based assays
September 20, 2017 Webinar: Create Your Own Cell-Based Assays to Study Receptor Tyrosine Kinase Function - 30 min.

What will be covered?

  • RTK biology and drug discovery importance
  • Tools needed to create your own RTK cell lines and assays
  • Experimental design and workflows
  • Applications of RTK and related cell-based assays
April 19, 2017 Webinar: Combining Target-Based and Phenotypic Discovery Assays for Drug Repurposing - 40 min.

What will be covered?

  • Using phenotypic profiling to characterize clinically successful drugs for a given indication
  • Combining target-based and phenotypic data to prioritize drugs for repurposing
  • Understanding how multi-targeted kinases can be pivoted towards new indications
September 30, 2016 Webinar: Immuno-Oncology Drug Development: Profiling Immunomodulatory Biologics and Compounds in Human Primary Cell-Based Oncology Models - 60 min.

What will be covered?

  • Overview of the BioMAP® immuno-oncology/oncology systems
  • Information BioMAP iOnc studies provide
  • Host stromal/vascular - tumor microenvironment biology
  • Case studies of profiling Ab therapies (anti-PD-1, anti-CTLA-4, etc.) and preclinical compounds
May 25, 2016 Webinar: A Phenotypic Platform for Characterization of Drug Safety Mechanisms in Human Primary Cell Disease Models - 40 min.

What will be covered?

  • How to maximize knowledge of your compounds using the BioMAP® Diversity PLUS™ panel of human primary cells systems
  • How to understand mechanism classification analysis and toxicity signatures
  • A case study on discovery of a mechanism-based novel signature for skin irritation