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GPCR Webinar Series

Accelerating GPCR drug discovery

In this webinar series, we showcase our comprehensive portfolio of G-protein coupled receptor (GPCR) assay solutions.  From basic pharmacology to trends in ligand bias/functional selectivity, and case studies in arrestin and second messenger signaling, this series has something for everyone.

Learn about creating your own GPCR assays here: Do-It-Yourself Webinars
 

Webinars will continue to be added to this series, so please check back often.

 


Event Date ▼ Event Name PDF Link Webinar Link
August 16, 2017 Webinar: Discovery of Bacterial Effectors in the Human Microbiome and Isolation of a GPCR G2A/GPR132 Agonist - 30 min.

What will be covered?

  • The role of GPCRs in regulating host-microbial interactions
  • How to identify microbial metabolites that modulate GPCR functions
  • A case study on defining host-microbial interaction and therapeutic potential of N-acyl amides, bacterial metabolites that activate GPR132/G2A
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April 5, 2017 Webinar: From Chemistry to Clinic: Discovery of Biased Apelin Receptor Agonists and Action in the Cardiovascular System - 55 min.

What will be covered?

  • Role of GPCRs in human cardiovascular system
  • Strategies for exploiting orphan GPCRs recently paired with endogenous ligands illustrated by Apelin and Elabela/Toddler
  • Identifying biased agonists using pharmacologically-relevant functional cell based assays
  • Validating assays and minimizing inter-assay variation
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March 9, 2017 Webinar: Mu Opioid Receptor Splicing and Signaling: Another Dimension of GPCR Function - 55 min.

What will be covered?

  • Overview of the mu opioid receptor signaling
  • GPCR splicing, using OPRM1 as an example
  • Region and cell specific splicing
  • Functional consequences of 5’ splicing
  • Functional consequences of 3’ splicing
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February 1, 2017 Webinar: Unlocking GPCRs for Oncology - 35 min.

What will be covered?

  • Opportunities and challenges for targeting GPCRs in oncology
  • Examples of GPCR-targeting investigational therapies for oncology
  • Imipridones, selective GPCR-targeting small molecules, that are in preclinical and clinical development for oncology
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November 9, 2016 Webinar: Duplexed Screening of GPCRs to Measure Calcium and β-Arrestin - 60 min.

What will be covered?

  • Screening approaches for GPCR drug discovery
  • Creating a duplexed assay to monitor calcium and β-arrestin in a single well
  • Determine potential bias for various drugs and define potency ranking
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July 27, 2016 Webinar: Understand Safety and Selectivity of Drug Candidates Before Expensive Animal Studies - 60 min.

What will be covered?

  • How PathHunter® GPCR Screening and Profiling Services can be used to triage hits, rank order compounds, and develop novel biased ligands
  • Tools to understand the mechanism of action of your drugs and their mode of action
  • How a case study of clinically approved drugs in our broad range of GPCR assays can be used to predict the selectivity and safety of your drug candidates
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May 19, 2016 Webinar: Ready-to-use Potency Assays for Anti-VEGF Drugs Like Bevacizumab, Ranibizumab & Aflibercept - 60 min.

What will be covered?

  • Creation of cell-based bioassays for potency and stability testing
  • Application, development and validation of assays with drug molecule
  • Case studies on Avastin (bevacizumab), Eylea (aflibercept) and Lucentis (ranibizumab)
  • Qualified assays for > 30 biosimilars
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May 12, 2016 Webinar: Latest Trends in Ligand Bias and Allosteric Modulators – New Opportunities, Insights and Prospects for Cure - 60 min.

What will be covered?

  • Capabilities overview of LeadHunter Discovery Services
  • Identifying, characterizing and quantifying novel biased ligands using LeadHunter Services
  • Multiple pathways including ß-Arrestin and how biased signaling can influence efficacy in vivo
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