| April 5, 2017 |
Webinar: From Chemistry to Clinic: Discovery of Biased Apelin Receptor Agonists and Action in the Cardiovascular System - 55 min.
What will be covered?
- Role of GPCRs in human cardiovascular system
- Strategies for exploiting orphan GPCRs recently paired with endogenous ligands illustrated by Apelin and Elabela/Toddler
- Identifying biased agonists using pharmacologically-relevant functional cell based assays
- Validating assays and minimizing inter-assay variation
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| March 9, 2017 |
Webinar: Mu Opioid Receptor Splicing and Signaling: Another Dimension of GPCR Function - 55 min.
What will be covered?
- Overview of the mu opioid receptor signaling
- GPCR splicing, using OPRM1 as an example
- Region and cell specific splicing
- Functional consequences of 5’ splicing
- Functional consequences of 3’ splicing
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| February 1, 2017 |
Webinar: Unlocking GPCRs for Oncology - 35 min.
What will be covered?
- Opportunities and challenges for targeting GPCRs in oncology
- Examples of GPCR-targeting investigational therapies for oncology
- Imipridones, selective GPCR-targeting small molecules, that are in preclinical and clinical development for oncology
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| November 9, 2016 |
Webinar: Duplexed Screening of GPCRs to Measure Calcium and β-Arrestin - 60 min.
What will be covered?
- Screening approaches for GPCR drug discovery
- Creating a duplexed assay to monitor calcium and β-arrestin in a single well
- Determine potential bias for various drugs and define potency ranking
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| July 27, 2016 |
Webinar: Understand Safety and Selectivity of Drug Candidates Before Expensive Animal Studies - 60 min.
What will be covered?
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How PathHunter® GPCR Screening and Profiling Services can be used to triage hits, rank order compounds, and develop novel biased ligands
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Tools to understand the mechanism of action of your drugs and their mode of action
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How a case study of clinically approved drugs in our broad range of GPCR assays can be used to predict the selectivity and safety of your drug candidates
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| June 15, 2016 |
Webinar: Make Your Own Cell-Based Assays to Study β-Arrestin Recruitment - 30 min.
What will be covered?
- Overview of β-arrestin biology
- Tools needed to create your own β-arrestin cell lines and assays
- Experimental design and workflows
- Applications of β-arrestin cell-based assays for GPCRs
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| May 19, 2016 |
Webinar: Ready-to-use Potency Assays for Anti-VEGF Drugs Like Bevacizumab, Ranibizumab & Aflibercept - 60 min.
What will be covered?
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Creation of cell-based bioassays for potency and stability testing
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Application, development and validation of assays with drug molecule
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Case studies on Avastin (bevacizumab), Eylea (aflibercept) and Lucentis (ranibizumab)
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Qualified assays for > 30 biosimilars
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| May 12, 2016 |
Webinar: Latest Trends in Ligand Bias and Allosteric Modulators – New Opportunities, Insights and Prospects for Cure - 60 min.
What will be covered?
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Capabilities overview of LeadHunter Discovery Services
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Identifying, characterizing and quantifying novel biased ligands using LeadHunter Services
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Multiple pathways including ß-Arrestin and how biased signaling can influence efficacy in vivo
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| September 24, 2015 |
Ligand Bias Simplified - A Novel Pharmacologic Toolbox - 30 min.
What will be covered
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Capabilities overview of LeadHunter Discovery Services
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How LeadHunter can be used to identify, characterize and quantify novel biased ligands
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Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo
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| June 4, 2015 |
Robust HitHunter® cAMP Assays for Biologics and Small Molecules - 30 min.
What will be covered?
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Overview of our novel enzyme fragment complementation technology
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Introduction to the assay principle
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Explore several applications for basic research and drug discovery (performing molecular profiling and identifying allosteric modulators, partial agonists, neutralizing Abs and more)
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| May 14, 2015 |
GPCR Profiling: Approaches for Characterizing Ligand Bias - 60 min.
What will be covered
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Capabilities overview of LeadHunter Discovery Services
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How LeadHunter can be used to identify and characterize novel biased ligands
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Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo
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| February 18, 2015 |
GPCR Profiling: A Robust Approach to Screening and Functional Characterization of GPCR Modulator - 60 min.
What will be covered
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Capabilities overview of LeadHunter Discovery Services
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Explore how LeadHunter can be used to triage hits, rank order compounds and develop novel biased ligands
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Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo
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| March 19, 2014 |
GPCR Webinar: Multi-Pathway GPCR Screening to Quantify Ligand Bias - 60 min.
What will be covered?
• Understand the utility of the three core technology platforms
• Learn how to uncover biased ligands by characterizing the same GPCR target in multiple pathway readouts
• Explore case studies on OPRD1, OPRM1, S1P1, Glucagon and Chemokine receptors |
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| February 20, 2014 |
GPCR Webinar: Internalization & Receptor Recycling - Essential Tools for GPCR Biology - 60 min.
What will be covered?
• Understand the PathHunter GPCR Internalization technology
• Discover how PathHunter can be used to differentiate between strongly internalizing & weakly internalizing compounds
• Explore how receptor trafficking and localization can impact the biological efficacy of a ligand |
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| May 29, 2013 |
GPCR Webinar: ß-Arrestin Signaling - The Pathway To Smarter, Safer and More Effective Drugs - 60 min.
What will be covered?
• Understand the PathHunter™ ß-Arrestin technology
• Discover how ß-Arrestin signaling correlates with compound activity in vivo
• Explore how Arrestin can be used to triage hits, rank order compounds & develop novel biased ligands |
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| February 27, 2013 |
How Will You Integrate Arrestin Into Your GPCR Programs This Year? - 60 min.
What will be covered?
• Description of the PathHunter Arrestin technology
• Key platform benefits
• Assay design and validation strategies
• Case studies showing correlation between in vitro and in vivo studies |
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