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GPCR Webinar Series

Accelerating GPCR drug discovery

In this webinar series, we showcase our comprehensive portfolio of G-protein coupled receptor (GPCR) assay solutions.  From basic pharmacology to trends in ligand bias/ functional selectivity and case studies in arrestin and second messenger signaling, this series has something for everyone. 
 
Webinars will continue to be added to this series, so please check back often.

 


Event Date ▼ Event Name PDF Link Webinar Link
April 5, 2017 Webinar: From Chemistry to Clinic: Discovery of Biased Apelin Receptor Agonists and Action in the Cardiovascular System - 55 min.

What will be covered?

  • Role of GPCRs in human cardiovascular system
  • Strategies for exploiting orphan GPCRs recently paired with endogenous ligands illustrated by Apelin and Elabela/Toddler
  • Identifying biased agonists using pharmacologically-relevant functional cell based assays
  • Validating assays and minimizing inter-assay variation
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March 9, 2017 Webinar: Mu Opioid Receptor Splicing and Signaling: Another Dimension of GPCR Function - 55 min.

What will be covered?

  • Overview of the mu opioid receptor signaling
  • GPCR splicing, using OPRM1 as an example
  • Region and cell specific splicing
  • Functional consequences of 5’ splicing
  • Functional consequences of 3’ splicing
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February 1, 2017 Webinar: Unlocking GPCRs for Oncology - 35 min.

What will be covered?

  • Opportunities and challenges for targeting GPCRs in oncology
  • Examples of GPCR-targeting investigational therapies for oncology
  • Imipridones, selective GPCR-targeting small molecules, that are in preclinical and clinical development for oncology
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November 9, 2016 Webinar: Duplexed Screening of GPCRs to Measure Calcium and β-Arrestin - 60 min.

What will be covered?

  • Screening approaches for GPCR drug discovery
  • Creating a duplexed assay to monitor calcium and β-arrestin in a single well
  • Determine potential bias for various drugs and define potency ranking
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July 27, 2016 Webinar: Understand Safety and Selectivity of Drug Candidates Before Expensive Animal Studies - 60 min.

What will be covered?

  • How PathHunter® GPCR Screening and Profiling Services can be used to triage hits, rank order compounds, and develop novel biased ligands
  • Tools to understand the mechanism of action of your drugs and their mode of action
  • How a case study of clinically approved drugs in our broad range of GPCR assays can be used to predict the selectivity and safety of your drug candidates
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June 15, 2016 Webinar: Make Your Own Cell-Based Assays to Study β-Arrestin Recruitment - 30 min.

What will be covered?

  • Overview of β-arrestin biology
  • Tools needed to create your own β-arrestin cell lines and assays
  • Experimental design and workflows
  • Applications of β-arrestin cell-based assays for GPCRs
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May 19, 2016 Webinar: Ready-to-use Potency Assays for Anti-VEGF Drugs Like Bevacizumab, Ranibizumab & Aflibercept - 60 min.

What will be covered?

  • Creation of cell-based bioassays for potency and stability testing
  • Application, development and validation of assays with drug molecule
  • Case studies on Avastin (bevacizumab), Eylea (aflibercept) and Lucentis (ranibizumab)
  • Qualified assays for > 30 biosimilars
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May 12, 2016 Webinar: Latest Trends in Ligand Bias and Allosteric Modulators – New Opportunities, Insights and Prospects for Cure - 60 min.

What will be covered?

  • Capabilities overview of LeadHunter Discovery Services
  • Identifying, characterizing and quantifying novel biased ligands using LeadHunter Services
  • Multiple pathways including ß-Arrestin and how biased signaling can influence efficacy in vivo
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September 24, 2015 Ligand Bias Simplified - A Novel Pharmacologic Toolbox - 30 min.

What will be covered

  • Capabilities overview of LeadHunter Discovery Services
  • How LeadHunter can be used to identify, characterize and quantify novel biased ligands
  • Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo
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June 4, 2015 Robust HitHunter® cAMP Assays for Biologics and Small Molecules - 30 min.

What will be covered?

  • Overview of our novel enzyme fragment complementation technology
  • Introduction to the assay principle
  • Explore several applications for basic research and drug discovery (performing molecular profiling and identifying allosteric modulators, partial agonists, neutralizing Abs and more)
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May 14, 2015 GPCR Profiling: Approaches for Characterizing Ligand Bias - 60 min.

What will be covered

  • Capabilities overview of LeadHunter Discovery Services
  • How LeadHunter can be used to identify and characterize novel biased ligands
  • Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo
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February 18, 2015 GPCR Profiling: A Robust Approach to Screening and Functional Characterization of GPCR Modulator - 60 min.

What will be covered

  • Capabilities overview of LeadHunter Discovery Services
  • Explore how LeadHunter can be used to triage hits, rank order compounds and develop novel biased ligands
  • Discover how multiple pathways including ß-Arrestin can influence efficacy in vivo
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March 19, 2014 GPCR Webinar: Multi-Pathway GPCR Screening to Quantify Ligand Bias - 60 min.

What will be covered?

• Understand the utility of the three core technology platforms
• Learn how to uncover biased ligands by characterizing the same GPCR target in multiple pathway readouts
• Explore case studies on OPRD1, OPRM1, S1P1, Glucagon and Chemokine receptors
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February 20, 2014 GPCR Webinar: Internalization & Receptor Recycling - Essential Tools for GPCR Biology - 60 min.

What will be covered?

• Understand the PathHunter GPCR Internalization technology
• Discover how PathHunter can be used to differentiate between strongly internalizing & weakly internalizing compounds
• Explore how receptor trafficking and localization can impact the biological efficacy of a ligand
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May 29, 2013 GPCR Webinar: ß-Arrestin Signaling - The Pathway To Smarter, Safer and More Effective Drugs - 60 min.

What will be covered?

• Understand the  PathHunter™ ß-Arrestin technology
• Discover how ß-Arrestin signaling correlates with compound activity in vivo
• Explore how Arrestin can be used to triage hits, rank order compounds & develop novel biased ligands
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February 27, 2013 How Will You Integrate Arrestin Into Your GPCR Programs This Year? - 60 min.

What will be covered?

• Description of the PathHunter Arrestin technology
• Key platform benefits
• Assay design and validation strategies
• Case studies showing correlation between in vitro and in vivo studies
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