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GPCR Webinar Series

Accelerating GPCR drug discovery

In this webinar series, we showcase our comprehensive portfolio of G-protein coupled receptor (GPCR) assay solutions.  From basic pharmacology to trends in ligand bias/functional selectivity, and case studies in arrestin and second messenger signaling, this series has something for everyone.

Learn about creating your own GPCR assays here: Do-It-Yourself Webinars

Webinars will continue to be added to this series, so please check back often.


Event Date ▼ Event Name PDF Link Webinar Link
December 6, 2017 Webinar: Application of β-Arrestin Assays to the Orphan GPCR World - 30 min.
April 5, 2017 Webinar: From Chemistry to Clinic: Discovery of Biased Apelin Receptor Agonists and Action in the Cardiovascular System - 55 min.

What will be covered?

  • Role of GPCRs in human cardiovascular system
  • Strategies for exploiting orphan GPCRs recently paired with endogenous ligands illustrated by Apelin and Elabela/Toddler
  • Identifying biased agonists using pharmacologically-relevant functional cell based assays
  • Validating assays and minimizing inter-assay variation
March 9, 2017 Webinar: Mu Opioid Receptor Splicing and Signaling: Another Dimension of GPCR Function - 55 min.

What will be covered?

  • Overview of the mu opioid receptor signaling
  • GPCR splicing, using OPRM1 as an example
  • Region and cell specific splicing
  • Functional consequences of 5’ splicing
  • Functional consequences of 3’ splicing
February 1, 2017 Webinar: Unlocking GPCRs for Oncology - 35 min.

What will be covered?

  • Opportunities and challenges for targeting GPCRs in oncology
  • Examples of GPCR-targeting investigational therapies for oncology
  • Imipridones, selective GPCR-targeting small molecules, that are in preclinical and clinical development for oncology
November 9, 2016 Webinar: Duplexed Screening of GPCRs to Measure Calcium and β-Arrestin - 60 min.

What will be covered?

  • Screening approaches for GPCR drug discovery
  • Creating a duplexed assay to monitor calcium and β-arrestin in a single well
  • Determine potential bias for various drugs and define potency ranking