| November 29, 2017 |
Webinar: Implementing ADCC assays in QC: When donor variability isn’t an option - 55 min.
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| November 1, 2017 |
Webinar: How to Accelerate Your Biotherapeutic Development with Cell-Based Assay Services - 40 min.
What will be covered?
- How PathHunter services save development time compared to in-house assays
- Screening and profiling biologics with highly specific and sensitive assays that produce robust and reproducible results
- Example data from marketed drugs, like Pembrolizumab and Nivolumab, using these cell-based assays
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| June 27, 2017 |
Webinar: Driving Robust ADCC and T Cell Redirection with KILR® CD16 Effector Cells - 55 min.
What will be covered?
- Eliminating donor variability in cytotoxicity assays with single donor-derived primary human KILR CD16 Effector Cells
- Better analysis of antibody’s cytotoxicity profile with better Hill Slopes and higher S:B compared to PBMCs
- Faster assessment of redirected T cell-mediated cytotoxicity with rapid killing kinetics of the CD16 Effector cells
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| March 10, 2017 |
免疫チェックポイント阻害剤の評価に適切なセルベースアッセイ系のご紹介 - 60 min.
What will be covered?
- 抗腫瘍免疫応答が増強に活用される免疫チェックポイント阻害剤の評価系
- PD-1, PD-L1, PD-L2, TWEAK, CD40, OX40, VISTA などの実施例
- 放射性同位体を使用しないADCC（抗体依存性細胞傷害）の評価系
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| September 9, 2016 |
DiscoverX：常に進化を続けている創薬・新薬開発市場への支援 - 60 min.
What will be covered?
- 2016の創薬市場：「スマート」になった現在の薬剤
- チェックポイント阻害剤の評価系・インターロイキン受容体・GPCR等
- キナーゼ阻害剤・エピジェネティック阻害剤・PPI創薬のスクリーニング
- 候補薬剤の表現型プロファイリング
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| June 29, 2016 |
Webinar: Building Relevant Cell-Based Assays for Co-Stimulatory and Co-Inhibitory Checkpoint Receptors - 60 min.
What will be covered?
- Novel cell-based assays for checkpoint signaling receptors
- Functional assays for biologics and small molecule screening
- Applications for QC lot release testing of biologics
- Assays for CD137, CTLA-4, TIGIT, PD-1, OX-40, CD40, TWEAK, TIM3, and VISTA
- Custom assay development for novel checkpoint targets
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| June 1, 2016 |
Webinar: Specifically Measure Target Cell Death for ADCC, ADCP, BiTe-like Bispecifics, and CAR-T - 45 min.
What will be covered?
- Simple cell-based assays to measure target cell cytotoxicity in a co-culture
- Assays for ADCC, ADCP, bi-specific antibody mediated T-cell redirection, and adoptive T-cell therapies such as CAR-T
- Enabling technology to drive a cancer immunotherapy drug through the discovery and development pipeline
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