Kappa agonist CovX-Bodies.

Authors: Roberts LR, Brady K, Brown A, Davey D, Feng L, Huang H, Liu D, Malet L, McMurray G, Phelan A, Saunders K and Bhat A.
Publisher/Year: Bioorg Med Chem Lett 22(12):4173-8.
Pub Med ID/Journal ID: PMID:22583618


Small peptidic kappa agonists were covalently linked to the reactive lysine of the CovX antibody to create compounds having potent activity at the kappa receptor with greatly extended half-life when compared to the parent peptide as exemplified by compound 20.