Detection of thyroid-stimulating immunoglobulins by use of enzyme-fragment complementation.

Authors: Sandrock T, Terry A, Martin JC, Erdogan E, Meikle WA.
Publisher/Year: Clin Chem. 2008 Aug;54(8):1401-2.
Pub Med ID/Journal ID: PMID:18664448


In Graves disease, autoantibodies activate thyroid-stimulating hormone (TSH)1 receptor, leading to hyperthyroidism caused by increases in intracellular cAMP and thyroid hormone. We developed a nonradioactive assay to measure thyroid-stimulating immunoglobulins (TSIs).