Characterization of compound mechanisms and secondary activities by BioMAP analysis.

Authors: Berg EL, Kunkel EJ, Hytopoulos E, Plavec I.
Publisher/Year: Journal of Pharmacological and Toxicological Methods. 2006;53(1):67–74.
Pub Med ID/Journal ID: PMID: 16040258

Abstract

Unexpected drug activities account for many of the failures of new chemical entities in clinical trials. These activities can be target-dependent, resulting from feedback mechanisms downstream of the primary target, or they can occur as a result of unanticipated secondary target(s). Methods that would provide rapid and efficient characterization of compounds with respect to a broad range of biological pathways and mechanisms relevant to human disease have the potential to improve preclinical and clinical success rates.