Can cell systems biology rescue drug discovery?

Authors: Butcher EC.
Publisher/Year: Nature Reviews Drug Discovery. 2005; 4(6):461–467.
Pub Med ID/Journal ID: PMID: 15915152


The focus of innovation in current drug discovery is on new targets, yet compound efficacy and safety in biological models of disease — not target selection — are the criteria that determine which drug candidates enter the clinic. We consider a biology-driven approach to drug discovery that involves screening compounds by automated response profiling in disease models based on complex human-cell systems. Drug discovery through cell systems biology could significantly reduce the time and cost of new drug development.