System ▲ | Relevance | Cell Type | Biomarker Readout |
/TH2 | Allergy, Asthma, Oncology | TH2 blasts + Venular endothelial cells | CCL2/MCP-1, CCL26/Eotaxin-3, CD106/VCAM-1, CD38, CD40, CD62E/E-Selectin, CD62P/P-Selectin, CD69, CD87/uPAR, Collagen IV, CXCL8/IL-8, CXCL9/MIG, PBMC Cytotoxicity, sIL-17A, sIL-17F, SRB |
BT | Allergy, Asthma, Autoimmunity, Oncology | B cells + Peripheral blood mononuclear cells | B cell Proliferation, PBMC Cytotoxicity, Secreted IgG, sIL-17A, sIL-17F, sIL-2, sIL-6, sTNF-α |
HDFSAg | Autoimmune Disease, Chronic Inflammation, Rheumatoid Arthritis | Dermal fibroblasts + Peripheral blood mononuclear cells | CCL2/MCP-1, CD106/VCAM-1, Collagen I, CXCL10/IP-10, CXCL8/IL-8, CXCL9/MIG, M-CSF, MMP-1, sIL-10, sIL-17A, sIL-17F, sIL-2, sIL-6, SRB, sTGF-β 1, sTNF-α, sVEGF |
SAg | Autoimmune Disease, Chronic Inflammation | Peripheral blood mononuclear cells + Venular endothelial cells | CCL2/MCP-1, CD38, CD40, CD62E/E-Selectin, CD69, CXCL8/IL-8, CXCL9/MIG, PBMC Cytotoxicity, Proliferation, SRB |