PathHunter® Protein Translocation Assays
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The movement of proteins between cellular compartments is essential for their specific biological role and the function of the cell. If these protein movements are altered by a ligand, protein mutations, or aberrant signaling, undesirable effects may occur, often resulting in drug tolerance, unwanted side effects, and disease. PathHunter protein translocation cell-based assays provide a high throughput, quantitative non-imaging approach to study trafficking of your protein of interest between different cellular compartments, and analyze the pharmacological effects of compounds on these translocations.