Apoptosis Signaling Pathway -

Targets

Apoptosis Pathway

Cancer cells are known to over-express a number of anti-apoptotic proteins that belong to the BCL2 family, on the surface of the mitochondria. These proteins interact with pro-apoptotic proteins and regulate the intrinsic apoptotic pathway by controlling the mitochondrial membrane permeability and release of the pro-apoptotic factor; Cytochrome c which initiates activation of the Caspase cascade and apoptosis.

Eurofins DiscoverX now offers a novel, direct, cell-based assays to study these apoptotic players. No more assay development required; you can obtain pre-validated biosensor cell lines that allows you to screen for protein interaction inhibitors (small molecules or siRNA) in a HTS-friendly and simple assay format!

Features and Benefits

Simple, HTS-friendly protocol

Whole cell, chemiluminescent assay

Avoid antibodies and lengthy FLOW based assay development

Applications

Broad applicability

Screen for small molecule inhibitors of protein interaction

Screen for siRNA

Assay List

Cell Lines

Target

Description