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CREB regulated transcription coactivator 2 (CRTC2)

Target Class
Pathway
Family
Transcription factor
Official Symbol
TORC2
Species
Human
Accession Number
NM_181715
Alias Names
CREB regulated transcription coactivator 2; CREB-regulated transcription coactivator 2; TORC-2; TORC2; transducer of regulated cAMP response element-binding protein (CREB) 2
Background
This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010]
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Related Group Members:

Transcription factor
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Assay Measures Background Species Cell Line
TORC2 Translocation U2OS Human 93-0813C3
Assay Measures Background Species Assay Kit
TORC2 Translocation U2OS Human 93-0813E3CP19S
TORC2 Translocation U2OS Human 93-0813E3CP19M
TORC2 Translocation U2OS Human 93-0813E3CP19L

KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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