Targets / Signaling Pathways / β-Catenin
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Catenin (cadherin-associated protein), beta 1 (CTNNB1)

Target Class
Pathway
Family
Wnt-Frizzled signalling
Official Symbol
β-Catenin
Species
Human
Accession Number
NM_001904
Alias Names
CTNNB; catenin (cadherin-associated protein), beta 1 (88kD); catenin (cadherin-associated protein), beta 1, 88kDa; catenin beta-1
Background
The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Oct 2009]AAK1
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Solution Portfolio

Related Group Members:

Wnt-Frizzled signalling
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family

Cell Lines
Assay Measures Background Species Cell Line
ß-catenin translocation U2OS Human 93-0743C3
Ready to Use eXpress Kits
Assay Measures Background Species Assay Kit
ß-Catenin Translocation U2OS Human 93-0743E3CP22M
ß-Catenin Translocation U2OS Human 93-0743E3CP22L

LeadHunter Screening & Profiling Services
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