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Nuclear receptor subfamily 3, group C, member 2 (Mineralcorticoid receptor) (NR3C2)

Target Class
NHR
Family
NHR
Official Symbol
MR
Species
Human
Accession Number
NM_000901
Alias Names
MCR; MLR; MR; NR3C2VIT; aldosterone receptor; mineralocorticoid receptor; mineralocorticoid receptor 1; mineralocorticoid receptor delta; nuclear receptor subfamily 3, group C, member 2
Background
This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
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Solution Portfolio

Technology:

Cell Based Protein Interaction
?

DiscoveRx Protein Interaction Assays are cell-based assays designed to measure protein interaction in engineered cell lines using our proprietary EFC technology. The interaction can be triggered by protein activation/inactivation and is the basis of several DiscoveRx cell based assays including the Arrestin and the Kinase assays. Learn more about our Cell Based Protein Interaction Assays.

, Cell Based Translocation
?

DiscoveRx Protein Translocation Assays are cell-based assays designed to measure protein translocation in engineered cell lines using our proprietary EFC technology. The translocation can occur to either the endosome, membrane, cytosol or nucleus and can be triggered by protein activation/inactivation. This forms the basis of several DiscoveRx cell based assays including the GPCR Internalization and the NHR Translocation assays. Learn more about our Cell Based Translocation Assays.

, Biochemical
?

DiscoveRx Biochemical Assays are designed as homogenous, competitive in vitro assays for precise, highly sensitive detection of specific analytes, protein binding or protease cleavage. These highly robust, reliable assays are anchored in our proprietary EFC technology, minimizing false positive due to autofluorescence and are HTS compatible. Learn more about our Biochemical Assays.


Related Target Members:

View
Assay Readout Background Species Cell Line
Chemiluminescence CHO-K1 Human 93-0451C2
Chemiluminescence CHO-K1 Human 93-0758C2
Assay Readout Background Species Assay Kit
Chemiluminescence CHO-K1 Human 93-0758H2CP13S
Chemiluminescence CHO-K1 Human 93-0758H2CP13M
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
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