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Nuclear receptor subfamily 1, group H, member 2 (Liver X receptor β) (NR1H2)

Target Class
NHR
Family
NHR
Official Symbol
LXRβ
Species
Human
Accession Number
NM_007121.4
Alias Names
LX receptor beta; LXR-b; LXRB; NER; NER-I; RIP15; UNR; liver X nuclear receptor beta; nuclear orphan receptor LXR-beta; nuclear receptor NER; nuclear receptor subfamily 1, group H, member 2; oxysterols receptor LXR-beta; steroid hormone-nuclear receptor NER; ubiquitously-expressed nuclear receptor
Background
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
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Solution Portfolio

Technology:

Cell Based Protein Interaction
?

DiscoveRx Protein Interaction Assays are cell-based assays designed to measure protein interaction in engineered cell lines using our proprietary EFC technology. The interaction can be triggered by protein activation/inactivation and is the basis of several DiscoveRx cell based assays including the Arrestin and the Kinase assays. Learn more about our Cell Based Protein Interaction Assays.

, Cell Based Translocation
?

DiscoveRx Protein Translocation Assays are cell-based assays designed to measure protein translocation in engineered cell lines using our proprietary EFC technology. The translocation can occur to either the endosome, membrane, cytosol or nucleus and can be triggered by protein activation/inactivation. This forms the basis of several DiscoveRx cell based assays including the GPCR Internalization and the NHR Translocation assays. Learn more about our Cell Based Translocation Assays.

, Biochemical
?

DiscoveRx Biochemical Assays are designed as homogenous, competitive in vitro assays for precise, highly sensitive detection of specific analytes, protein binding or protease cleavage. These highly robust, reliable assays are anchored in our proprietary EFC technology, minimizing false positive due to autofluorescence and are HTS compatible. Learn more about our Biochemical Assays.


Related Target Members:

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Assay Readout Background Species Cell Line
Chemiluminescence CHO-K1 Human 93-0442C2
Assay Readout Background Species Assay Kit
Chemiluminescence CHO-K1 Human 93-0442H2CP13S
Chemiluminescence CHO-K1 Human 93-0442H2CP13M
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan