Find a Product

Nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1)

Target Class
NHR
Family
NHR
Official Symbol
GR
Species
Human
Accession Number
NM_000176
Alias Names
GCCR; GCR; GR; GRL; glucocorticoid nuclear receptor variant 1; glucocorticoid receptor; nuclear receptor subfamily 3, group C, member 1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
Background
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
+ Show More


Solution Portfolio

Technology:

Cell Based Protein Interaction
?

DiscoveRx Protein Interaction Assays are cell-based assays designed to measure protein interaction in engineered cell lines using our proprietary EFC technology. The interaction can be triggered by protein activation/inactivation and is the basis of several DiscoveRx cell based assays including the Arrestin and the Kinase assays. Learn more about our Cell Based Protein Interaction Assays.

, Cell Based Translocation
?

DiscoveRx Protein Translocation Assays are cell-based assays designed to measure protein translocation in engineered cell lines using our proprietary EFC technology. The translocation can occur to either the endosome, membrane, cytosol or nucleus and can be triggered by protein activation/inactivation. This forms the basis of several DiscoveRx cell based assays including the GPCR Internalization and the NHR Translocation assays. Learn more about our Cell Based Translocation Assays.

, Biochemical
?

DiscoveRx Biochemical Assays are designed as homogenous, competitive in vitro assays for precise, highly sensitive detection of specific analytes, protein binding or protease cleavage. These highly robust, reliable assays are anchored in our proprietary EFC technology, minimizing false positive due to autofluorescence and are HTS compatible. Learn more about our Biochemical Assays.


Related Target Members:

View
Assay Readout Background Species Cell Line
Chemiluminescence CHO-K1 Human 93-0002C2
Chemiluminescence CHO-K1 Human 93-0456C2
Assay Readout Background Species Assay Kit
Chemiluminescence CHO-K1 Human 93-0456H2CP13S
Chemiluminescence CHO-K1 Human 93-0456H2CP13M
Chemiluminescence CHO-K1 Human 93-0002H2CP13S
Chemiluminescence CHO-K1 Human 93-0002H2CP13M
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
      Available