sterile alpha motif and leucine zipper containing kinase AZK (ZAK)

Target Class
Official Symbol
Entrez Gene ID
Accession Number
Alias Names
AZK; HCCS-4; MLK-like mitogen-activated protein triple kinase; MLK7; MLT; MLTK; MRK; human cervical cancer suppressor gene 4 protein; mitogen-activated protein kinase kinase kinase MLT; mixed lineage kinase 7; mixed lineage kinase with a leucine zipper and a sterile alpha motif; mixed lineage kinase-related kinase MRK-beta; mlklak; pk; sterile alpha motif and leucine zipper containing kinase AZK
This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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Related Group Members: TKL

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