Biological Information | |
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Background Information: | ZAK is a member of the MAPKKK family of signal transduction molecules and is a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
Target Class: | Kinase |
Accession Number: | NM_016653.2 |
Target Name: | ZAK |
Target Species: | Human |
Usage | |
Product Type: | Enzymes |
Application: | Drug Discovery & Development |
Storage Conditions: | 1 year at -70°C |
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ZAK, active
N-terminal GST-tagged, recombinant, human ZAK full length expressed by baculovirus in Sf21 insect cells. Purified using glutathione agarose.
Datasheets
15-015x Datasheet
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