Targets / Kinase / TRPM6

Transient receptor potential cation channel, subfamily M, member 6 (TRPM6)

Target Class
Kinase
Family
Atypical
Official Symbol
TRPM6
Entrez Gene ID
140803
Species
Human
Accession Number
NP_060132.3
Alias Names
CHAK2; HMGX; HOMG; HOMG1; HSH; channel kinase 2; hypomagnesemia, secondary hypocalcemia; melastatin-related TRP cation channel 6; transient receptor potential cation channel subfamily M member 6; transient receptor potential cation channel, subfamily M, member 6
Background
This gene is predominantly expressed in the kidney and colon, and encodes a protein containing an ion channel domain and a protein kinase domain. It is crucial for magnesium homeostasis, and plays an essential role in epithelial magnesium transport and in the active magnesium absorption in the gut and kidney. Mutations in this gene are associated with hypomagnesemia with secondary hypocalcemia. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Apr 2010]
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