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Neurotrophic tyrosine kinase receptor type 1 (NTRK1)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
TrkA
Species
Human
Accession Number
NM_002529
Alias Names
MTC; Oncogene TRK; TRK; TRK1; TRK1-transforming tyrosine kinase protein; TRKA; Trk-A; gp140trk; high affinity nerve growth factor receptor; neurotrophic tyrosine kinase, receptor, type 1; p140-TrkA; tropomyosin-related kinase A; tyrosine kinase receptor A
Background
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0462C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0462E3CP16S
Receptor Phosphorylation U2OS Human 93-0462E3CP16M
Receptor Phosphorylation U2OS Human 93-0462E3CP16L
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available