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Platelet-derived growth factor receptor beta (PDGFRb)

Target Class
Kinase
Family
Receptor Tyrosine Kinase
Official Symbol
PDGFRB
Species
Human
Accession Number
NM_002609
Alias Names
CD140 antigen-like family member B; CD140B; JTK12; PDGF-R-beta; PDGFR; PDGFR-1; PDGFR-beta; PDGFR1; beta-type platelet-derived growth factor receptor; platelet-derived growth factor receptor 1; platelet-derived growth factor receptor beta; platelet-derived growth factor receptor, beta polypeptide
Background
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia. [provided by RefSeq, Jul 2008]
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Solution Portfolio

Related Group Members: Receptor Tyrosine Kinase
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DiscoveRx offers cell-based assays that target other members of this gene family or functional group. Click on the family name to browse all available assays for that target family


Assay Measures Background Species Cell Line
Receptor Phosphorylation U2OS Human 93-0493C3
Assay Measures Background Species Assay Kit
Receptor Phosphorylation U2OS Human 93-0493E3CP16S
Receptor Phosphorylation U2OS Human 93-0493E3CP16M
Receptor Phosphorylation U2OS Human 93-0493E3CP16L
SH2 Recruitment U2OS Human 93-0493Y3-00074
SH2 Recruitment U2OS Human 93-0493Y3-00073
KINOMEscan TKscan BROMOscan NHRscan GPCRscan PATHscan
Available Available